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Preventive Effect of Melatonin on the Progression of α-Naphthylisothiocyanate-induced Acute Liver Injury in Rats by Yoshiji Ohta; Mutsumi Kongo; Teruaki Kishikawa is a Neuroscience article available to read on EtoBox.

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**Abstract:** The preventive effect of melatonin on the progression of __α__‐naphthylisothiocyanate (ANIT)‐induced acute liver injury with cholestasis was examined in rats treated once with the hepatotoxin [75 mg/kg body weight (BW), i.p.]. In rats treated with ANIT alone, liver injury with cholestasis occurred 24 hr after treatment and progressed at 48 hr, judging from the serum levels of hepatobiliary marker enzymes and components. Melatonin (10 or 100 mg/kg BW) was orally administered to the ANIT‐treated rats, 24 hr after the hepatotoxin treatment at which time hepatic injury had already developed. The administered indoleamine prevented the progression of liver cell damage rather than biliary cell damage more effectively at the higher dose than at the lower dose. In rats treated with ANIT alone, the serum and hepatic concentrations of thiobarbituric acid reactive substances, an index of lipid peroxidation, and the hepatic activity of myeloperoxidase, an index of tissue neutrophil infiltration, increased 24 hr after treatment and further increased at 48 hr. In the liver of rats treated with ANIT alone, Cu,Zn‐superoxide dismutase activity decreased 24 hr after treatment and was fu

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Author

Yoshiji Ohta; Mutsumi Kongo; Teruaki Kishikawa

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0742-3098)

Published

2003

Language

EN

Field

Neuroscience (Life Sciences)