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Dominantly Inherited Micro-Satellite Instable Cancer - The Four Lynch Syndromes - An EHTG, PLSD Position Statement by walter pavicic is a document available to read on EtoBox.

This document discusses the four Lynch syndromes, which are dominantly inherited cancer syndromes caused by pathogenic variants in mismatch repair genes. It highlights the impact of colonoscopy surveillance, penetrance, and expressivity of these genes on cancer incidence and survival rates, emphasizing the need for personalized precision medicine approaches such as aspirin prevention and immunotherapy. The findings suggest that while early cancers are often curable, subsequent cancers in other organs pose s

Author

walter pavicic

Language

EN