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Vitamin C (ascorbate) and lipoic acid were found to kill tumor cells in hollow fibre in vitro models at clinically achievable concentrations, both alone and in combination. Lipoic acid synergistically enhanced ascorbate cytotoxicity. Intravenous ascorbate infusions of 25 g in humans produced peak plasma concentrations exceeding 25 μM with an area under the curve of 125 μM*h, achieving tumoricidal levels. Ascorbate efficacy was also increased additively by phenyl ascorbate and vitamin E. A Chinese study foun

Author

Paolo Milan

Language

EN