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Can I read Iodine landmark paper: Pituitary nuclear 3,5,3′‐triiodothyronine and thyrotropin secretion: An explanation for the effect of thyroxine on EtoBox?
Iodine landmark paper: Pituitary nuclear 3,5,3′‐triiodothyronine and thyrotropin secretion: An explanation for the effect of thyroxine by Antonio C. Bianco; Marla J. Berry is a Nursing article available to read on EtoBox.
What is Iodine landmark paper: Pituitary nuclear 3,5,3′‐triiodothyronine and thyrotropin secretion: An explanation for the effect of thyroxine about?
Iodine is an essential component of thyroid hormones. The thyroglobulin-derived iodothyronine molecules contain 3 or 4 iodine atoms that are covalently bound during iodide organification. This process, also known as iodination, is catalyzed by thyroid peroxidase and requires that the thyroid cell concentrate iodide from plasma. Iodine is readily available from the ocean, and salt-water vertebrates, the first life forms to develop a thyroid gland, are not at risk for iodine deficiency. However, in terrestrial vertebrates, including humans, iodine availability can be limiting depending on the proximity to the ocean and the iodine content of the soil. Iodine content and structural localization in various thyroid products determine the biological potency of thyroid secretions. As an example, the prohormone 3,3Ј,5,5Јtetraiodothyronine (T4), which contains 4 iodine atoms, must undergo outer-ring monodeiodination to 3,3Ј,5-triiodothyronine (T3) in order to achieve its full biological potency. This process is catalyzed primarily by the type 1 5Ј-deiodinase (D1), a propylthiuracyl (PTU) sensitive enzyme expressed in most tissues [1]. While the role of iodine in thyroid hormone action and me
Who reads Iodine landmark paper: Pituitary nuclear 3,5,3′‐triiodothyronine and thyrotropin secretion: An explanation for the effect of thyroxine?
It is typically read by researchers, students, and practitioners in Nursing.
- Author
- Antonio C. Bianco; Marla J. Berry
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0896-548X)
- Published
- 2001
- Language
- EN
- Field
- Nursing (Health Sciences)