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Abnormal bile acids in the Smith‐Lemli‐Opitz syndrome by Marvin R. Natowicz; James E. Evans is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The urinary bile acids from four patients with Smith‐Lemli‐Opitz (SLO) syndrome were analyzed by continuous flow fast atom bombardment mass spectrometry. Two types of abnormalities were noted: (1) a deficiency of normal bile acids (cholenoates) and (2) the presence of abnormal species postulated to be cholenoates and cholestenoates. The finding of abnormal urinary bile acids in children with SLO syndrome led to further investigation of the cholesterol metabolic pathway and to the delineation of a new inborn error of metabolism, deficient conversion of 7‐dehy‐drocholesterol to cholesterol [Irons et al., 1993]. The abnormalities of urinary bile acids, if confirmed by further structural analyses and studies of additional patients, provide an explanation for various aspects of the gastrointestinal abnormalities and growth retardation noted in SLO syndrome and suggest that exogenous bile acid replacement may play an important role in the therapy of patients with this syndrome. © 1994 Wiley‐Liss, Inc.

Who reads Abnormal bile acids in the Smith‐Lemli‐Opitz syndrome?

Author

Marvin R. Natowicz; James E. Evans

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0148-7299)

Published

1994

Language

SL

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)