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Molecular mechanism of PSORI-CM01 for psoriasis by regulating the inflammatory cytokines network by Mingxiang Xie; Miaomiao Zhang; Yuanyuan Qiao; Yibing Yang; Fuda Xie; Lichun Chen; Na Liu; Jiangyong Gu is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Molecular mechanism of PSORI-CM01 for psoriasis by regulating the inflammatory cytokines network about?
Ethnopharmacological relevance Psoriasis is an inflammatory skin disease, there is no radical cure. Traditional Chinese medicine has accumulated a lot of clinical experience in the treatment of psoriasis and developed a variety of treatment methods, among which Yinxieling optimization formula (PSORI-CM01) have a definite clinical effect in the treatment of psoriasis, but their mechanism of action is still unclear. Aim of the study To investigate the molecular mechanism of the PSORI-CM01 in the treatment of psoriasis. Materials and methods Firstly, potential active compounds and key signaling pathways of PSORI-CM01 were explored by the systems pharmacology method. Then MTT assay was used to screen the potentially active compounds of PSORI-CM01, and explore the combined effects of potentially active compounds. The regulation of potentially active compounds on inflammatory factors were evaluated by a Human Th17 Magnetic Bead Panel. The regulation of PSORI-CM01 on key targets in the key signaling pathways were explored by qRT-PCR method. Finally, the molecular mechanism of PSORI-CM01 in the treatment of psoriasis was explained by the systems pharmacology method. Results The potentially
Who reads Molecular mechanism of PSORI-CM01 for psoriasis by regulating the inflammatory cytokines network?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Mingxiang Xie; Miaomiao Zhang; Yuanyuan Qiao; Yibing Yang; Fuda Xie; Lichun Chen; Na Liu; Jiangyong Gu
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)