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The Cardioprotective Potentials and the Involved Mechanisms of Phenolic Acids in Drug-induced Cardiotoxicity by Xianfeng Liu; Ruimin Tian; Honglin Tao; Jiasi Wu; Lu Yang; Yi Zhang; Xianli Meng is a Neuroscience article available to read on EtoBox.

What is The Cardioprotective Potentials and the Involved Mechanisms of Phenolic Acids in Drug-induced Cardiotoxicity about?

Cardiotoxicity is one of the major safety concerns in the use of drug and is the most common reason for drug removal from the market. At present, several drugs that have been recognized as the clinically effective drug have been reported to be associated with a high risk of cardiotoxicity during clinical use. The most representative ones are doxorubicin, arsenic trioxide, isoproterenol, cyclophosphamide, etc. The adverse effects seriously affect the human health and limit the clinical application of the drugs mentioned above. Over the past years, many strategies have been carried out to prevent the occurrence of drug-induced cardiotoxicity, including early detection of cardiotoxicity by biomarkers, limitation of doses, changing of drug-delivery way, combining with cardioprotective agent. Among them, combining with cardioprotective agent has gained increased interest and has been considered as a promising approach for continued treatment. Therefore, looking for effective cardioprotective agent to avoid the occurrence of drug-induced cardiotoxicity has become a great challenge for many researchers. Interestingly, some phenolic acids compounds from natural plants have been demonstrate

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Author

Xianfeng Liu; Ruimin Tian; Honglin Tao; Jiasi Wu; Lu Yang; Yi Zhang; Xianli Meng

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Neuroscience (Life Sciences)