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shown in our paper, where the NTCP for avoiding complications in any of two tissues are compared between two plans (2). Table 1 of that paper shows that the ranking of two plans according to the probability of being free from complications can change simply by multiplying the individual complication probability estimates by a constant correction factor. If so, the ranking of the two plans according to the TCP/NTCP ratio will be reversed, too, by a proportional change to the complication probability estimates of the individual tissues. Of course, there is no guarantee that the ordering across plans of the TCP or NTCP for any one tissue is correct. Claims for improved dose distributions using some of the newer technologies are often based on scores formed from these probability estimates without benefit of any error display. Demonstration of improvement according to the historic rules for prescribing plans such as minimum tumor dose or dose-volume limits on normal tissues may be lacking. If novel technologies, often costly and with uncertain risk, are to substitute for standard treatments, it will be important to show that estimated gains in the risk of complication or recurrence mee

Who reads Correspondence?

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

1999

Language

SR

Field

Medicine (Health Sciences)