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Randomized Controlled Trial of Letrozole, Berberine, or a Combination for Infertility in the Polycystic Ovary Syndrome by Xiao-Ke Wu; Yong-Yan Wang; Jian-Ping Liu; Rui-Ning Liang; Hui-Ying Xue; Hong-Xia Ma; Xiao-Guang Shao; Ernest H.Y. Ng; Li-Hui Hou; Yong-Yan Wang; Feng Tian; Yan-Ming Xie; Jin-Feng Zhang; Ya-Qin Gao; Shao-Min Du; Ying Yan; Pei-Lin Li; Jin-Ying Fu; Wei-Li Li; Zhen-Yu Tan; Feng-Jie He; Cai-Fei Ding; Xiao-Bin Li; Xian-Ji Shen; Mu-Er An; Guang-Zhu Yu; Robert M. Silver; Elisabet Stener-Victorin is a Medicine article available to read on EtoBox.

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## Objective: To study whether a combination of berberine and letrozole results in higher live births than letrozole alone in infertile women with polycystic ovary syndrome (pcos). ## Design: A multicenter randomized double-blinded placebo-controlled trial. ## Setting: Reproductive and developmental network sites. ## Patient(s): Eligible women had pcos as defined by the rotterdam criteria. we enrolled 644 participants randomized 1:1:1 among letrozole, berberine, and combination groups. ## Interventions(s): Berberine or berberine placebo were administrated orally at a daily dose of 1.5 g for up to 6 months. patients received an initial dose of 2.5 mg letrozole or placebo on days 3-7 of the first three treatment cycles. this dose was increased to 5 mg on the last three cycles if not pregnant. ## Main outcomes measure(s): Cumulative live births. ## Results: The cumulative live births were similar between the letrozole and combination groups after treatment (36% and 34%), and were superior to those in the berberine group (22%). likely, conception, pregnancy, and ovulation rates were similar between the letrozole and combination groups, and these were significantly higher than in the be

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Author

Xiao-Ke Wu; Yong-Yan Wang; Jian-Ping Liu; Rui-Ning Liang; Hui-Ying Xue; Hong-Xia Ma; Xiao-Guang Shao; Ernest H.Y. Ng; Li-Hui Hou; Yong-Yan Wang; Feng Tian; Yan-Ming Xie; Jin-Feng Zhang; Ya-Qin Gao; Shao-Min Du; Ying Yan; Pei-Lin Li; Jin-Ying Fu; Wei-Li Li; Zhen-Yu Tan; Feng-Jie He; Cai-Fei Ding; Xiao-Bin Li; Xian-Ji Shen; Mu-Er An; Guang-Zhu Yu; Robert M. Silver; Elisabet Stener-Victorin

Published

2016

Language

EN

Field

Medicine (Health Sciences)