About this Medicine article
More on vitamin E therapy by Pietro Vajro; Claudia Mandato; Adriana Franzese; Stefania Lucariello is a Medicine article available to read on EtoBox.
We read with great interest the recent article by Kugelmas et al., 1 reporting plasma cytokine levels in patients with NASH and the effect of diet and vitamin E on this disease. They found that plasma tumor necrosis factor (TNF), interleukin 8, and interleukin 6 concentrations were significantly elevated compared with control values, and only plasma interleukin 6 levels significantly decreased with diet therapy. This article further reported that vitamin E therapy did not independently influence the biochemical data and plasma cytokine levels in patients with NASH. We previously investigated the plasma transforming growth factor-1 (TGF-1) level and the efficacy of vitamin E in patients with NASH. 2 We enrolled 12 patients with NASH and 10 with fatty liver. All patients were given dietary instruction for 6 months, and thereafter vitamin E (␣-tocopherol acetate, JuveraTM, Eisai Pharmaceutical Co., Tokyo, Japan, 300 mg/day; 100 mg is equivalent to 100 IU) was given for 1 year. In consequence, the plasma TGF-1 level in patients with NASH (37 Ϯ 5 ng/ml) was significantly higher than that in patients with fatty liver (10 Ϯ 4 ng/ml) and healthy subjects (9 Ϯ 5 ng/ml). Moreover, this el
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- Author
- Pietro Vajro; Claudia Mandato; Adriana Franzese; Stefania Lucariello
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)