Can I read Clinical outcomes of concomitant rifamycin and opioid therapy: A systematic review on EtoBox?

Clinical outcomes of concomitant rifamycin and opioid therapy: A systematic review by Eric M. Kinney; Sandhya Vijapurapu; Jordan R. Covvey; Branden D. Nemecek is a Medicine article available to read on EtoBox.

What is Clinical outcomes of concomitant rifamycin and opioid therapy: A systematic review about?

## Abstract Opioids are one of the most prescribed classes of analgesic medications. Their narrow therapeutic index and metabolism through cytochrome p450 (CYP) enzymes can result in a drug interaction when used concomitantly with rifamycins. In clinical scenarios where concurrent therapy with an opioid and a rifamycin occurs, there is no standardized guidance for managing the interaction. The objective of this review was to examine literature which evaluates the concomitant use of opioids and rifamycins with clinically relevant CYP‐inducing properties. A systematic review following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) criteria was performed. PubMed, Scopus, and OVID Embase were queried for studies from database inception to January 2020 related to rifamycin and opioid medications. Only full‐text, peer‐reviewed, English language articles addressing clinical outcomes from concomitant rifamycin and opioid therapy were included. The review isolated 12 articles for data extraction from an original 2260 citations identified. Rifampin (11; 92%) and rifabutin (2; 17%) were the rifamycins studied along with seven different opioids. Decreased effec

Who reads Clinical outcomes of concomitant rifamycin and opioid therapy: A systematic review?

Author

Eric M. Kinney; Sandhya Vijapurapu; Jordan R. Covvey; Branden D. Nemecek

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)