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Fabrication of Poly(propylene Fumarate)-based Orthopaedic Implants by Photo-crosslinking Through Transparent Silicone Molds by Mark D. Timmer; Cory Carter; Catherine G. Ambrose; Antonios G. Mikos is a Engineering article available to read on EtoBox.

What is Fabrication of Poly(propylene Fumarate)-based Orthopaedic Implants by Photo-crosslinking Through Transparent Silicone Molds about?

This work presents a new molding process for photo-crosslinked, degradable polymeric networks of poly(propylene fumarate) (PPF) and the crosslinking agent poly(propylene fumarate)-diacrylate (PPF-DA). Transparent room temperature vulcanizing silicone molds were fabricated for parts ranging from simple test coupons to orthopaedic implants. The PPF/PPF-DA resin blend was injected into the cavity and photo-crosslinked as light was transmitted through the mold wall. The volumetric shrinkage, mechanical properties, and the effects of gamma sterilization were reported for molded PPF/PPF-DA networks prepared with varying compositions of the two polymer components. The shrinkage decreased while the mechanical properties displayed a general increasing trend when more of the crosslinking agent was incorporated into the network. Gamma irradiation resulted in an improvement of the mechanical properties. In addition, PPF/PPF-DA replicates of a 70:30 poly(L/DL-lactide) biodegradable fixation plate and a bone allograft interbody fusion spacer were produced to evaluate the performance of PPF/PPF-DA as an orthopaedic implant and allow for a comparison to be made with materials that have been establ

Who reads Fabrication of Poly(propylene Fumarate)-based Orthopaedic Implants by Photo-crosslinking Through Transparent Silicone Molds?

Author

Mark D. Timmer; Cory Carter; Catherine G. Ambrose; Antonios G. Mikos

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)

Published

2003

Language

EN

Field

Engineering (Physical Sciences)