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Performance of a dipstick dye immunoassay for rapid screening of Schistosoma japonicum infection in areas of low endemicity by Jing Xu; Ting Feng; Dan-Dan Lin; Qi-Zhi Wang; Li Tang; Xiao-Hua Wu; Jia-Gang Guo; Rosanna W Peeling; Xiao-Nong Zhou is a Medicine article available to read on EtoBox.
What is Performance of a dipstick dye immunoassay for rapid screening of Schistosoma japonicum infection in areas of low endemicity about?
## Background The dipstick dye immunoassay (DDIA), recently commercially available in the People's Republic of China (P.R. China), is a rapid and simple test to detect human antibodies against __Schistosoma Japonicum__. Its performance and utility for screening schistosome infection in low endemic areas is little known. We therefore carried out a cross-sectional survey in seven villages with low endemicity of schistosomiasis in P.R. China and assessed the performance and utility of DDIA for diagnosis of schistosomiasis. Stool samples were collected and examined by the Kato-Katz method and the miracidium hatching technique. Serum samples, separated from whole blood of participants, were tested by DDIA. ## Results 6285 individuals aged 6-65 years old participated in this study, with a prevalence of schistosomiasis of 4.20%. Using stool examination as a gold reference standard, DDIA performed with a high overall sensitivity of 91.29% (95% CI: 87.89-94.69%) and also a high negative predictive value, with a mean value of 99.29% (95% CI: 98.99-99.58%). The specificity of DDIA was only moderate (53.08%, 95% CI: 51.82-54.34%). Multivariate analysis indicated that age, occupation and histor
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- Author
- Jing Xu; Ting Feng; Dan-Dan Lin; Qi-Zhi Wang; Li Tang; Xiao-Hua Wu; Jia-Gang Guo; Rosanna W Peeling; Xiao-Nong Zhou
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2008-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc.; Research Square (ISSN 1756-3305)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)