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Labeling of articular cartilage surface with cationized ferritin: Aged human normal and osteoarthritic cartilage by Dr. Ritta Stanescu; Victor Stanescu; Jacques Peyron is a Medicine article available to read on EtoBox.

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The labeling of the articular surface with cationized ferritin (CF), an electron-dense marker, visualizes the anionic sites and may disclose abnormal penetration of the large C F molecule into the subsurface layers. Various areas of cartilage selected by unaided eye examination were taken from femoral heads excised in three cases of osteoarthritis and two cases of hip fracture. The fragments were examined by optical microscopy and by electron microscopy after labeling with CF. The labeling with and the penetration of CF were correlated with the morphological features of the surface. The surfaces belonging to the erosion border were disrupted and the C F penetrated approximately 2 pm into the matrix along the collagen fibers and in areas containing a patchy dense material. Prefixation with Karnovsky's fixative prevents C F penetration. The fragments taken at a distance from the erosion border showed at electron microscopical examination either an intact appearance of the surface that was labeled without penetration or a disrupted surface with penetration of the label. The osteophytes and the regeneration buds surface were labeled showing little or no penetration. The fragments from

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Author

Dr. Ritta Stanescu; Victor Stanescu; Jacques Peyron

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)

Published

1984

Language

EN

Field

Medicine (Health Sciences)