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Expression of TSLC1, a candidate tumor suppressor gene mapped to chromosome 11q23, is downregulated in unfavorable neuroblastoma without promoter hypermethylation by Kiyohiro Ando; Miki Ohira; Toshinori Ozaki; Atsuko Nakagawa; Kohei Akazawa; Yusuke Suenaga; Yohko Nakamura; Tadayuki Koda; Takehiko Kamijo; Yoshinori Murakami; Akira Nakagawara is a Medicine article available to read on EtoBox.

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## Abstract Although it has been well documented that loss of human chromosome 11q is frequently observed in primary neuroblastomas, the smallest region of overlap (SRO) has not yet been precisely identified. Previously, we performed array‐comparative genomic hybridization (array‐CGH) analysis for 236 primary neuroblastomas to search for genomic aberrations with high‐resolution. In our study, we have identified the SRO of deletion (10‐Mb or less) at 11q23. Within this region, there exists a __TSLC1/IGSF4/CADM1__ gene (__Tumor suppressor in lung cancer 1/Immunoglobulin superfamily 4/Cell adhesion molecule 1__), which has been identified as a putative tumor suppressor gene for lung and some other cancers. Consistent with previous observations, we have found that 35% of primary neuroblastomas harbor loss of heterozygosity (LOH) on __TSLC1__ locus. In contrast to other cancers, we could not detect the hypermethylation in its promoter region in primary neuroblastomas as well as neuroblastoma‐derived cell lines. The clinicopathological analysis demonstrated that __TSLC1__ expression levels significantly correlate with stage, Shimada's pathological classification, __MYCN__ amplification s

Who reads Expression of TSLC1, a candidate tumor suppressor gene mapped to chromosome 11q23, is downregulated in unfavorable neuroblastoma without promoter hypermethylation?

Author

Kiyohiro Ando; Miki Ohira; Toshinori Ozaki; Atsuko Nakagawa; Kohei Akazawa; Yusuke Suenaga; Yohko Nakamura; Tadayuki Koda; Takehiko Kamijo; Yoshinori Murakami; Akira Nakagawara

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2008

Language

EN

Field

Medicine (Health Sciences)