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Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity – the SWEET Project by Catherine Gibbons; Beverley O'Hara; Dominic O’Connor; Charlotte Hardman; Moon Wilton; Joanne A Harrold; Eva Almiron-Roig; Santiago Navas-Carretero; Charo E Hodgkins; Julie Anne Nazare; Maud Alligier; Jose Alfredo Martínez; Corey Scott; Louise Kjølbæk; Mie Normand; Cécile Rannou; Ellen E Blaak; Edith Feskens; Hariklia Moshoyiannis; Anne Raben; Jason C G Halford; Kristine Beaulieu; Graham Finlayson is a Medicine article available to read on EtoBox.

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## Introduction Intake of free sugars in European countries is high and attempts to reduce sugar intake have been mostly ineffective. Non-nutritive sweeteners and sweetness enhancers (S&SEs) can maintain sweet taste in the absence of energy, but little is known about the impact of acute and repeated consumption of S&SE in foods on appetite. This study aims to evaluate the effect of acute and repeated consumption of two individual S&SEs and two S&SE blends in semisolid and solid foods on appetite and related behavioural, metabolic and health outcomes. ## Methods and analysis A work package of the SWEET Project; this study consists of five double-blind randomised cross-over trials which will be carried out at five sites across four European countries, aiming to have n=213. Five food matrices will be tested across three formulations (sucrose-sweetened control vs two reformulated products with S&SE blends and no added sugar). Participants (body mass index 25–35 kg/m^2^; aged 18–60 years) will consume each formulation for 14 days. The primary endpoint is composite appetite score (hunger, inverse of fullness, desire to eat and prospective food consumption) over a 3-hour postprandial incr

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Author

Catherine Gibbons; Beverley O'Hara; Dominic O’Connor; Charlotte Hardman; Moon Wilton; Joanne A Harrold; Eva Almiron-Roig; Santiago Navas-Carretero; Charo E Hodgkins; Julie Anne Nazare; Maud Alligier; Jose Alfredo Martínez; Corey Scott; Louise Kjølbæk; Mie Normand; Cécile Rannou; Ellen E Blaak; Edith Feskens; Hariklia Moshoyiannis; Anne Raben; Jason C G Halford; Kristine Beaulieu; Graham Finlayson

Publisher

BMJ

Published

2022

Language

EN

Field

Medicine (Health Sciences)