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Fast Microglial Activation After Severe Traumatic Brain Injuries by Lier, Julia; Ondruschka, Benjamin; Bechmann, Ingo; DreÃler, Jan is a Medicine article available to read on EtoBox.

What is Fast Microglial Activation After Severe Traumatic Brain Injuries about?

## Abstract Traumatic brain injury is among the leading causes of death in individuals under 45 years of age. However, since trauma mechanisms and survival times differ enormously, the exact mechanisms leading to the primary and secondary injury and eventually to death after traumatic brain injury (TBI) remain unclear. Several studies showed the versatile functions of microglia, the innate macrophages of the brain, following a TBI. Earlier being characterized as rather neurotoxic, neuroprotective capacities were recently demonstrated, therefore, making microglia one of the key players following TBI. Especially in cases with only short survival times, immediate microglial reactions are of great forensic interest in questions of wound age estimation. Using standardized immunohistochemical methods, we examined 8 cases which died causatively of TBI with survival times between minutes and 7 days and 5 control cases with cardiovascular failure as the cause of death to determine acute changes in microglial morphology and antigen expression after TBI. In this pilot study, we detected highly localized changes in microglial morphology already early after traumatic damage, e.g., activated mic

Who reads Fast Microglial Activation After Severe Traumatic Brain Injuries?

Author

Lier, Julia; Ondruschka, Benjamin; Bechmann, Ingo; DreÃler, Jan

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0937-9827)

Published

2020

Language

EN

Field

Medicine (Health Sciences)