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Accelerated Radiotherapy with Delayed Concomitant Boost in Locally Advanced Squamous Cell Carcinoma of the Head and Neck by Robert MacKenzie; Judith Balogh; Richard Choo; Edmee Franssen is a Medicine article available to read on EtoBox.

What is Accelerated Radiotherapy with Delayed Concomitant Boost in Locally Advanced Squamous Cell Carcinoma of the Head and Neck about?

Purpose: To determine the toxicity, maximum tolerated dose (MTD), and clinical effectiveness of a 5-week course of accelerated radiotherapy with delayed concomitant boost in locally advanced squamous cell carcinoma of the head and neck (SCCHN). Methods and Materials: Thirty-five patients with untreated T3T4NM0 or TN2 (> 3 cm) N3M0 SCC of the oral cavity, oropharynx, hypopharynx, or larynx were entered in the study between January 1994 and October 1997. The initial target volume was treated with conventional daily fractions. A small field boost covering gross disease was added as a second daily fraction during the last 2 weeks of the 5-week schedule, using a minimum interfraction interval of 6 h. The study was initiated using 180-cGy fractions to deliver a total dose of 63 Gy over 33-35 days. A classical dose escalation strategy was planned to increase the delivered dose in steps using minimum cohorts of three patients, up to a maximum of 70 Gy in 200-cGy fractions. Results: In the dose escalation study, 4 patients were entered at level 1 (63 Gy), 9 at level 2 (65 Gy), and 8 at level 3 (67 Gy). One patient was withdrawn at level 2 because of unstable angina, and 1 at level 3 because

Who reads Accelerated Radiotherapy with Delayed Concomitant Boost in Locally Advanced Squamous Cell Carcinoma of the Head and Neck?

Author

Robert MacKenzie; Judith Balogh; Richard Choo; Edmee Franssen

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

1999

Language

EN

Field

Medicine (Health Sciences)