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GSNOR and ALDH2 alleviate traumatic spinal cord injury by Mushfiquddin Khan; Fei Qiao; S.M. Touhidul Islam; Tajinder S. Dhammu; Pavan Kumar; Jeseong Won; Avtar K. Singh; Inderjit Singh is a Neuroscience article available to read on EtoBox.
What is GSNOR and ALDH2 alleviate traumatic spinal cord injury about?
Traumatic spinal cord injury (SCI) enhances the activity of S-nitrosoglutathione reductase (GSNOR) and inhibits the mitochondrial aldehyde dehydrogenase 2 (ALDH2) activity, resulting in prolonged and sustained pain and functional deficits. This study's objective was to test the hypotheses that GSNOR's specific inhibitor N6022 mitigates pain and improves functional recovery in a mouse model of SCI. Furthermore, the degree of recovery is enhanced and the rate of recovery is accelerated by an ALDH2 activator Alda-1. Using both wild-type and GSNOR/ mice, the SCI model deployed for groups was contusion at the T9-T10 vertebral level. The enzymatic activity of GSNOR and ALDH2 was measured, and the expression of GSNOR and ALDH2 was determined by western blot analysis. Functional improvements in experimental animals were assessed with locomotor, sensorimotor, and pain-like behavior tests. Wild-type SCI animals had enhanced GSNOR activity and decreased ALDH2 activity, leading to neurovascular dysfunction, edema, and worsened functional outcomes, including locomotor deficits and pain. Compared to wild-type SCI mice, GSNOR/ mice had better functional outcomes. Monotherapy with either GSNOR inh
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It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Mushfiquddin Khan; Fei Qiao; S.M. Touhidul Islam; Tajinder S. Dhammu; Pavan Kumar; Jeseong Won; Avtar K. Singh; Inderjit Singh
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Neuroscience (Life Sciences)