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Atrophic gastritis during long‐term omeprazole therapy affects serum vitamin B~12~ levels by Schenk; Kuipers; Klinkenberg‐Knol; Bloemena; Sandell; Nelis; Snel; Festen; Meuwissen is a Medicine article available to read on EtoBox.

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## Background : Omeprazole maintenance therapy for gastro‐oesophageal reflux disease (GERD) has been associated with an increased incidence of atrophic gastritis in __H. pylori‐__infected patients and with a decreased absorption of protein‐bound, but not of unbound cobalamin. ## Aim : To test the hypothesis that the combination of decreased cobalamin absorption and atrophic gastritis decreases serum cobalamin levels during omeprazole therapy. ## Methods : Forty‐nine __H. pylori‐__positive GERD patients were treated with omeprazole for a mean (± s.d.) period of 61 (25) months. At the start of omeprazole treatment (T~0~) and at the latest follow‐up visit (T~1~), serum was obtained for measurement of cobalamin. Corpus biopsy specimens were obtained at entry and follow‐up for histopathological scoring according to the updated Sydney classification. ## Results : At inclusion, none of the 49 patients had signs of atrophic gastritis. During follow‐up, 15 patients (33%) developed atrophic gastritis, nine of whom had moderate to severe atrophy. These 15 patients did not differ from the other 34 patients with respect to age, serum cobalamin at T~0~ or the duration of follow‐up. During follow

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Author

Schenk; Kuipers; Klinkenberg‐Knol; Bloemena; Sandell; Nelis; Snel; Festen; Meuwissen

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

1999

Language

EN

Field

Medicine (Health Sciences)