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Modulation of cholinergic, GABA-ergic and glutamatergic components of superior colliculus affect REM sleep in rats by Yashaswee Mishra; Birendra Nath Mallick is a Neuroscience article available to read on EtoBox.
What is Modulation of cholinergic, GABA-ergic and glutamatergic components of superior colliculus affect REM sleep in rats about?
The superior colliculus (SC) is associated with visual attention, spatial navigation, decision making, escape and approach responses, some of which are important for defence and survival in rodents. SC helps in initiating and controlling saccadic eye movements and gaze during wakefulness. It is also activated during rapid eye movement (REM) sleep associated rapid eye movements (REMs). To investigate the contribution of SC in sleep-wake behaviour, we have demonstrated that manipulation of SC with scopolamine, carbachol, muscimol, picrotoxin and MK-801 decreased the amount of REM sleep. We observed that scopolamine and picrotoxin as well as muscimol decreased REM sleep frequency. MK-801 decreased percent amount of REM sleep, however, neither the frequency nor the duration/episode was affected. The cholinergic and GABA-ergic modulation of SC affecting REM sleep may be involved in REM sleep associated visuo-spatial learning and memory consolidation, which however, need to be confirmed. Furthermore, the results suggest involvement of efferent from SC in modulation of sleep-waking via the brainstem sleep regulating areas.
Who reads Modulation of cholinergic, GABA-ergic and glutamatergic components of superior colliculus affect REM sleep in rats?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Yashaswee Mishra; Birendra Nath Mallick
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Neuroscience (Life Sciences)