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Characterization and Developmental Expression of Lactotriosylceramider: Galactosyltransferase for the Synthesis of Neolactotetraosylceramide in the Nervous System by Denise K. H. Chou; Firoze B. Jungalwala is a Neuroscience article available to read on EtoBox.
What is Characterization and Developmental Expression of Lactotriosylceramider: Galactosyltransferase for the Synthesis of Neolactotetraosylceramide in the Nervous System about?
Abstract: Neolactoglycolipids are derived from neolactotetraosylceramide (nLcOse~4~Cer). They are found during the embryonic and neonatal developmental periods in the rat cerebral cortex and disappear shortly after birth. These glycolipids are, however, abundant in the adult cerebellum. Lactotriosylceramide (LcOse~3~Cer):galactosyltrans‐ ferase (GT), which catalyzes the terminal step in the biosynthesis of nLcOse~4~Cer, was characterized in mammalian brain. The enzyme was highly specific for LcOse~3~Cer, with a terminal GlcNAcβ1 ‐3Gal‐residue, and it did not catalyze the transfer of galactose to other glycolipids studied with alternate carbohydrate residues. The microsomal membrane enzyme required Mn^2+^ and a detergent for in vitro activity. The optimal pH was 7.4, and the __K__~m~ value for LcOse~3~Cer was 34 μ__M__ (V~max~=∼2 nmol/mg/h). The LcOse~3~Cer:GT was shown to be different from the GM2:GT and the soluble enzyme lactose synthase A. The specific activity of LcOse~3~Cer:GT was enriched fivefold higher in the white matter than in the gray matter of young adult rat brain, whereas GM2:GT was enriched only about 1.5‐fold higher in the white matter. The developmental expressio
Who reads Characterization and Developmental Expression of Lactotriosylceramider: Galactosyltransferase for the Synthesis of Neolactotetraosylceramide in the Nervous System?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Denise K. H. Chou; Firoze B. Jungalwala
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 1994
- Language
- EN
- Field
- Neuroscience (Life Sciences)