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Narcolepsy with Cataplexy by Yves Dauvilliers; Isabelle Arnulf; Emmanuel Mignot is a Social Sciences article available to read on EtoBox.

What is Narcolepsy with Cataplexy about?

Narcolepsy with cataplexy is a disabling sleep disorder aff ecting 0•02% of adults worldwide. It is characterised by severe, irresistible daytime sleepiness and sudden loss of muscle tone (cataplexy), and can be associated with sleeponset or sleep-off set paralysis and hallucinations, frequent movement and awakening during sleep, and weight gain. Sleep monitoring during night and day shows rapid sleep onset and abnormal, shortened rapid-eye-movement sleep latencies. The onset of narcolepsy with cataplexy is usually during teenage and young adulthood and persists throughout the lifetime. Pathophysiological studies have shown that the disease is caused by the early loss of neurons in the hypothalamus that produce hypocretin, a wakefulness-associated neurotransmitter present in cerebrospinal fl uid. The cause of neural loss could be autoimmune since most patients have the HLA DQB1\*0602 allele that predisposes individuals to the disorder. Treatment is with stimulant drugs to suppress daytime sleepiness, antidepressants for cataplexy, and γ hydroxybutyrate for both symptoms. Because narcolepsy is an under-recognised disease, it is important that general practitioners and other primary

Who reads Narcolepsy with Cataplexy?

Author

Yves Dauvilliers; Isabelle Arnulf; Emmanuel Mignot

Publisher

Elsevier BV

Published

2007

Language

EN

Field

Social Sciences