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Systemic inflammation and protease profile of Afro-Caribbean patients with sepsis by Borhanjoo, Panid (author);Singh, Navneet (author);Nath, Sridesh (author);Chowdhury, MD Sadakat (author);Swanson, Carl (author);Kaiser, Ryan (author);Geraghty, Patrick (author);Foronjy, Robert F (author);Chow, Lillian (author) is a Medicine article available to read on EtoBox.

What is Systemic inflammation and protease profile of Afro-Caribbean patients with sepsis about?

## Objectives: Sepsis is one of the leading causes of morbidity and mortality within the healthcare system and remains a diagnostic and therapeutic challenge. A major issue in the diagnosis of sepsis is understanding the pathophysiologic mechanism, which revolves around host immune system activation and dysregulated responses. African Americans are more likely to experience severe sepsis with higher mortality rates compared to the general population. This pilot study characterized multiple inflammatory markers and proteases in plasma of primarily African American and Afro-Caribbean patients with mild sepsis. ## Methods: Plasma was collected from 16 healthy controls and 15 subjects presenting with sepsis, on admission, and again upon resolution of the signs of sepsis, defined as a resolution of sepsis criteria. Plasma samples were analyzed for cytokines, chemokines, and proteases using multiplex bead assays. ## Results: Elevated levels of granulocyte colony-stimulating factor, interleukin-10, interleukin-15, interleukin-1 receptor antagonist, interleukin-8, interferon gamma-induced protein 10, monocyte chemoattractant protein-1, matrix metallopeptidase 12, and cathepsin S were ident

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Author

Borhanjoo, Panid (author);Singh, Navneet (author);Nath, Sridesh (author);Chowdhury, MD Sadakat (author);Swanson, Carl (author);Kaiser, Ryan (author);Geraghty, Patrick (author);Foronjy, Robert F (author);Chow, Lillian (author)

Publisher

SAGE Publications

Published

2021

Language

EN

Field

Medicine (Health Sciences)