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Stereolithography of Spatially Controlled Multi-material Bioactive Poly(ethylene Glycol) Scaffolds by Karina Arcaute; Brenda Mann; Ryan Wicker is a Engineering article available to read on EtoBox.
What is Stereolithography of Spatially Controlled Multi-material Bioactive Poly(ethylene Glycol) Scaffolds about?
Challenges remain in tissue engineering to control the spatial, mechanical, temporal and biochemical architectures of scaffolds. Unique capabilities of stereolithography (SL) for fabricating multi-material spatially controlled bioactive scaffolds were explored in this work. To accomplish multi-material builds, a mini-vat setup was designed allowing for self-aligning X-Y registration during fabrication. The mini-vat setup allowed the part to be easily removed and rinsed, and different photocrosslinkable solutions to be easily removed and added to the vat. Two photocrosslinkable hydrogel biopolymers, poly(ethylene glycol) dimethacrylate (PEG-dma, MW 1000) and poly(ethylene glycol) diacrylate (PEG-da, MW 3400), were used as the primary scaffold materials. Multi-material scaffolds were fabricated by including controlled concentrations of fluorescently labeled dextran, fluorescently labeled bioactive PEG or bioactive PEG in different regions of the scaffold. The presence of the fluorescent component in specific regions of the scaffold was analyzed with fluorescent microscopy, while human dermal fibroblast cells were seeded on top of the fabricated scaffolds with selective bioactivity an
Who reads Stereolithography of Spatially Controlled Multi-material Bioactive Poly(ethylene Glycol) Scaffolds?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Karina Arcaute; Brenda Mann; Ryan Wicker
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1742-7061)
- Published
- 2010
- Language
- EN
- Field
- Engineering (Physical Sciences)