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Is Vascular Remodelling in Patients with Chronic Heart Failure Exaggerated? by Robert Pietschner; Agnes Bosch; Dennis Kannenkeril; Kristina Striepe; Mario Schiffer; Stephan Achenbach; Roland E. Schmieder; Julie Kolwelter is a Medicine article available to read on EtoBox.

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## Abstract ## Background Vascular remodelling of large arteries increases afterload of the left ventricle. The aim of this study was to analyse whether vascular remodelling and function under laboratory and 24‐hour ambulatory conditions is impaired in patients with chronic heart failure (CHF) independently of cardiovascular risk factors. ## Methods and results In this monocentric cross‐sectional observational study, 105 patients with CHF and an ejection fraction ≤49% (CHF+) were compared to 118 subjects without CHF (CHF−). After adjustment for age, gender, arterial hypertension, hyperlipidaemia, type 2 diabetes, obesity and smoking, vascular function and structure parameters, as assessed by pulse wave analysis (SphygmoCor) and the UNEX EF device, respectively, between the CHF+ and the CHF− group differed for resting pulse wave velocity (PWV) (__P__ = 0.010), 24‐h ambulatory PWV (__P__ = 0.011), central systolic blood pressure (cSBP) (__P__ = <0.001), 24‐h ambulatory cSBP (__P__ = <0.001), resting central augmentation index (__P__ = 0.002), and brachial intima–media thickness (__P__ = 0.022). In CHF+ patients, higher levels of NT‐proBNP, taken as a marker for the severity of CHF, w

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Author

Robert Pietschner; Agnes Bosch; Dennis Kannenkeril; Kristina Striepe; Mario Schiffer; Stephan Achenbach; Roland E. Schmieder; Julie Kolwelter

Publisher

Wiley

Published

2022

Language

EN

Field

Medicine (Health Sciences)