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What is Grapefruit Juice Increases Sunitinib Levels about?
This study investigated the effect of grapefruit juice (GJ) on steady-state pharmacokinetics of sunitinib in cancer patients. Patients received sunitinib for 14-20 days to reach steady-state, then took GJ for 3 days. Sunitinib exposure was compared with and without GJ coadministration. GJ increased sunitinib exposure by 11% and midazolam exposure by 50%, confirming GJ
- Author
- Arina Iruka
- Language
- EN