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Coenzyme Q10 suppresses oxLDL‐induced endothelial oxidative injuries by the modulation of LOX‐1‐mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway by Kun‐Ling Tsai; Li‐Hsin Chen; Shih‐Hwa Chiou; Guang‐Yuh Chiou; Yu‐Chih Chen; Hsiang‐Yun Chou; Liang‐Kung Chen; Hsiao‐Yun Chen; Tsan‐Hung Chiu; Chiou‐Sheng Tsai; Hsiu‐Chung Ou; Chung‐Lan Kao is a Medicine article available to read on EtoBox.

What is Coenzyme Q10 suppresses oxLDL‐induced endothelial oxidative injuries by the modulation of LOX‐1‐mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway about?

## Abstract **Scope**: The lectin‐like oxidized low‐density lipoprotein receptor (LOX‐1) is one pivot receptor for oxidized low‐density lipoprotein (oxLDL) in human endothelial cells. Co‐enzyme Q10 (Co Q10) has been widely used in clinical intervention. However, the molecular mechanisms underlying its protective effects against oxidative stress in endothelial cells are still largely unknown. This study was designed to test the hypothesis that Co Q10 mitigates oxLDL‐induced endothelial oxidative injuries via modulation of LOX‐1‐mediated reactive oxygen species (ROS) generation and explored the role of AMP‐activated protein kinase (AMPK), a negative regulator of NADPH oxidase. **Methods and results**: Human umbilical vein endothelial cells (HUVECs) were pretreated with Co Q10 and then incubated with oxLDL for 24 h. Co Q10 attenuated oxLDL‐elicited LOX‐1 expression and ROS generation by suppression of NADPH oxidase activation. Co Q10 rescued dephosphorylation of AMPK caused by oxLDL that in turn led to an activation of NADPH oxidase by PKC. The results were confirmed using AMPK siRNA. Moreover, oxLDL‐suppressed Akt/eNOS and enhanced p38 phosphorylation, which in turn activated NF‐κB p

Who reads Coenzyme Q10 suppresses oxLDL‐induced endothelial oxidative injuries by the modulation of LOX‐1‐mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway?

Author

Kun‐Ling Tsai; Li‐Hsin Chen; Shih‐Hwa Chiou; Guang‐Yuh Chiou; Yu‐Chih Chen; Hsiang‐Yun Chou; Liang‐Kung Chen; Hsiao‐Yun Chen; Tsan‐Hung Chiu; Chiou‐Sheng Tsai; Hsiu‐Chung Ou; Chung‐Lan Kao

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1613-4125)

Published

2011

Language

EN

Field

Medicine (Health Sciences)