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Is Selective Internal Radioembolization Safe and Effective for Patients with Inoperable Hepatocellular Carcinoma and Venous Thrombosis? by Charles E. Woodall; Charles R. Scoggins; Susan F. Ellis; Clifton M. Tatum; Michael J. Hahl; Kadiyala V. Ravindra; Kelly M. McMasters; Robert C.G. Martin II is a Medicine article available to read on EtoBox.

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## BACKGROUND: The goal of this study was to examine the safety and efficacy of selective internal radioembolization (SIR) for hepatocellular carcinoma (HCC) with portal vein or caval thrombosis (VT), or both. Recent reports have demonstrated that SIR is safe for patients with HCC, but the impact on efficacy of venous thrombosis is unknown. STUDY DESIGN: Prospective single-arm study of the use of Therasphere in patients with unresectable HCC enrolled from January 2004 to June 2007. Patients were categorized into three groups based on VT status and therapy. ## RESULTS: Fifty-two patients were enrolled: 20 patients without VT who received SIR, 15 patients with VT who were treated, and 17 patients (10 with VT) who were not treated because of preprocedure screening failure. Fifty-eight treatments were administered, with a median of two treatments per patient (range of one to three treatments). Child's score was different between groups. Of the VT patients treated, 67% had portal VT, 7% had cava VT, and 26% had both. There were no treatment-related deaths. There was no difference in complications among groups (p ϭ 0.34). Treated patients without thrombosis had a median overall survival

Who reads Is Selective Internal Radioembolization Safe and Effective for Patients with Inoperable Hepatocellular Carcinoma and Venous Thrombosis??

Author

Charles E. Woodall; Charles R. Scoggins; Susan F. Ellis; Clifton M. Tatum; Michael J. Hahl; Kadiyala V. Ravindra; Kelly M. McMasters; Robert C.G. Martin II

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2009

Language

EN

Field

Medicine (Health Sciences)