Opening book details…
Can I read Development and Evaluation of Self-Emulsifying Drug-Delivery System–Based Tablets for Simvastatin, a BCS Class II Drug on EtoBox?
Development and Evaluation of Self-Emulsifying Drug-Delivery System–Based Tablets for Simvastatin, a BCS Class II Drug by Muhammad Anwar Bashir; Amjad Khan; Sayyed Ibrahim Shah; Majeed Ullah; Fazli Khuda; Muhammad Abbas; Khang Wen Goh; Long Chiau Ming is a Medicine article available to read on EtoBox.
What is Development and Evaluation of Self-Emulsifying Drug-Delivery System–Based Tablets for Simvastatin, a BCS Class II Drug about?
## Background Self-emulsifying drug-delivery systems (SEDDSs) are designed to improve the oral bioavailability of poorly water-soluble drugs. This study aimed at formulating and characterization of SEDDS-based tablets for simvastatin using castor and olive oils as solvents and Tween 60 as surfactant. ## Methods The liquids were adsorbed on microcrystalline cellulose, and all developed formulations were compressed using 10.5 mm shallow concave round punches. ## Results The resulting tablets were evaluated for different quality-control parameters at pre- and postcompression levels. Simvastatin showed better solubility in a mixture of oils and Tween 60 (10:1). All the developed formulations showed lower self-emulsification time (˂200 seconds) and higher cloud point (˃60°C). They were free of physical defects and had drug content within the acceptable range (98.5%–101%). The crushing strength of all formulations was in the range of 58–96 N, and the results of the friability test were within the range of USP (≤1). Disintegration time was within the official limits (NMT 15 min), and complete drug release was achieved within 30 min. ## Conclusion Using commonly available excipients and ma
Who reads Development and Evaluation of Self-Emulsifying Drug-Delivery System–Based Tablets for Simvastatin, a BCS Class II Drug?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Muhammad Anwar Bashir; Amjad Khan; Sayyed Ibrahim Shah; Majeed Ullah; Fazli Khuda; Muhammad Abbas; Khang Wen Goh; Long Chiau Ming
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)