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Pharmacology of G-1–64, a new nondepolarizing neuromuscular blocking agent with rapid onset and short duration of action by L. Gyermek; C. Lee; N. Nguyen is a Medicine article available to read on EtoBox.

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Background: Chances are slim that a clinically useful ultra‐short‐acting neuromuscular blocking agent of rapid onset will emerge from the benzylisoquinolinium or the aminosteroid series to which all currently popular relaxants belong. G‐1–64 is a promising prototype of a new series of bis‐quaternary ammonium salt of bistropinyl diester derivatives we have synthesized and studied in the laboratory. Methods: Neuromuscular block (NMB) and autonomic and cardiovascular side effects were studied on appropriate preparations of anesthetized rats, rabbits, cats, ferrets, pigs and monkeys. Neuromuscular blocking characteristics, cumulativeness, and pharmacological reversibility were determined. Cardiac vagal block was evaluated by the inhibition of the bradycardic response to stimulation of the vagus in the cat, rat, ferret, and pig. Sympathetic ganglion block was evaluated on the cat's superior cervical ganglion/nictitating membrane preparation. Arterial blood pressure and heart rate were determined in all species. Results: G‐1–64 produced nondepolarizing NMB with train‐of‐four (TOF) and tetanic fades, and reversible with anticholinesterases. Its ED~50~ ranged between 60 and 800 μg/kg in th

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Author

L. Gyermek; C. Lee; N. Nguyen

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-5172)

Published

1999

Language

EN

Field

Medicine (Health Sciences)