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Can I read Synthesis of Peptide and Pseudopeptide Amides Inhibiting the Proliferation of Small Cell and Epithelial Types of Lung Carcinoma Cells on EtoBox?
Synthesis of Peptide and Pseudopeptide Amides Inhibiting the Proliferation of Small Cell and Epithelial Types of Lung Carcinoma Cells by Olga Nyéki; Attila Rill; István Schőn; Antal Orosz; János Schrett; László Bartha; József Nagy is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis of Peptide and Pseudopeptide Amides Inhibiting the Proliferation of Small Cell and Epithelial Types of Lung Carcinoma Cells about?
Small cell lung cancer (SCLC) cell lines produce and secrete various peptide hormones, e.g. bombesin (BN)/gastrin releasing peptide (GRP) like peptides that are proposed to function as their autocrine growth factors. To inhibit the proliferative effect of these hormones we have synthesized short chain BN[7-14]-analogues replacing the C-terminal peptide bond by a methylene-amino (-CH 2 NH-) unit and introducing D-Phe or D-Ser into position 12. As several substance P (SP) analogues were found to inhibit the growth of SCLC cells, some short chain SP-analogues have been synthesized. (Pseudo)octapeptides were synthesized in solution, by fragment condensation using the DCC/HOPfp method. Fragments and SP-analogues were synthesized stepwise using pentafluorophenyl esters. The resistance to hydrolysis of the reduced peptide bond made permitted exact quantification of the Leu(CH 2 NH)Leu pseudopeptide in hydrolysates. The binding ability of both types of peptides to BN-receptors on Swiss 3T3 mouse fibroblast cells and their antiproliferative effect on NCI-H69 human SCLC cell line have been tested and compared with a short chain SP-antagonist pHOPA-D-Trp-Phe-D-Trp-Leu-Leu-NH 2 (R) previously
Who reads Synthesis of Peptide and Pseudopeptide Amides Inhibiting the Proliferation of Small Cell and Epithelial Types of Lung Carcinoma Cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Olga Nyéki; Attila Rill; István Schőn; Antal Orosz; János Schrett; László Bartha; József Nagy
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1075-2617)
- Published
- 1998
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)