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Interferon-High Immunophenotype in CRC by lingling.zhangwang is a document available to read on EtoBox.
Acha-Sagredo et al. identify a constitutive interferon-high immunophenotype in colorectal cancer (CRC) that predicts response to immunotherapy, particularly in patients with high CD74 expression. This immunophenotype is characterized by a tumor microenvironment rich in cytotoxic lymphocytes and antigen-presenting macrophages, and is present in both mismatch repair deficient (dMMR) and proficient (pMMR) CRCs. The findings suggest that CD74 abundance can serve as a biomarker for selecting patients likely to b
- Author
- lingling.zhangwang
- Language
- EN