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Inflammation and Cholesterol as Predictors of Cardiovascular Events Among Patients Receiving Statin Therapy: a Collaborative Analysis of Three Randomised Trials by Ridker, Paul M (author);Bhatt, Deepak L (author);Pradhan, Aruna D (author);Glynn, Robert J (author);MacFadyen, Jean G (author);Nissen, Steven E (author) is a nonfiction available to read on EtoBox.

What is Inflammation and Cholesterol as Predictors of Cardiovascular Events Among Patients Receiving Statin Therapy: a Collaborative Analysis of Three Randomised Trials about?

Background Inflammation and hyperlipidaemia jointly contribute to atherothrombotic disease. However, when people are treated with intensive statin therapy, the relative contributions of inflammation and hyperlipidaemia to the risk of future cardiovascular events might change, which has implications for the choice of adjunctive cardiovascular therapeutics. We aimed to evaluate the relative importance of high-sensitivity C-reactive protein (CRP) and low-density lipoprotein cholesterol (LDLC) as determinants of risk for major adverse cardiovascular events, cardiovascular death, and all-cause-death among patients receiving statins. Methods We did a collaborative analysis of patients with—or at high risk of—atherosclerotic disease, who were receiving contemporary statins and were participants in the multinational PROMINENT (NCT03071692), REDUCE-IT (NCT01492361), or STRENGTH (NCT02104817) trials. Quartiles of increasing baseline high-sensitivity CRP (a biomarker of residual inflammatory risk) and of increasing baseline LDLC (a biomarker of residual cholesterol risk) were assessed as predictors of future major adverse cardiovascular events, cardiovascular death, and all-cause death. Hazar

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Author

Ridker, Paul M (author);Bhatt, Deepak L (author);Pradhan, Aruna D (author);Glynn, Robert J (author);MacFadyen, Jean G (author);Nissen, Steven E (author)

Publisher

Elsevier BV

Published

2023

Language

EN

Category

nonfiction