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Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype by Payaningal R. Somanath; Eugene A. Podrez; Juhua Chen; Yi Ma; Kandice Marchant; Marina Antoch; Tatiana V. Byzova is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype about?
## Abstract Aging is associated with both the disturbances of circadian rhythms and a prothrombotic phenotype. It remains poorly understood how the circadian system regulates thrombosis, a critical outcome of aging‐related cardiovascular disease. Using multiple in vivo models, we now show that mice with genetic ablation of the core clock gene __Bmal1__, which display pre‐mature aging, have a dramatic prothrombotic phenotype. This phenotype is mechanistically linked to changes in the regulation of key risk factors for cardiovascular disease. These include circulating vWF, fibrinogen, and PAI‐1, all of which are significantly elevated in __Bmal1__^__−/−__^ mice. We also show that major circadian transcriptional regulators __CLOCK__ and __Bmal1__ directly regulate the activity of vWF promoter and that lack of __Bmal1__ results in upregulation of vWF both at mRNA and protein level. Here we report a direct regulation of vWF expression in endothelial cells by biological clock gene __Bmal1__. This study establishes a mechanistic connection between __Bmal1__ and cardiovascular phenotype. J. Cell. Physiol. 226: 132–140, 2010. © 2010 Wiley‐Liss, Inc.
Who reads Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Payaningal R. Somanath; Eugene A. Podrez; Juhua Chen; Yi Ma; Kandice Marchant; Marina Antoch; Tatiana V. Byzova
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)