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Epidemiology and Molecular-Pathologic Characteristics of CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer by Shailesh M. Advani; Michael D. Swartz; Jonathan Loree; Jennifer S. Davis; Amir Mehvarz Sarsashek; Michael Lam; Michael Sangmin Lee; Jan Bressler; David S. Lopez; Carrie R. Daniel; Van Morris; Imad Shureqi; Bryan Kee; Arvind Dasari; Eduardo Vilar; Michael Overman; Stanley Hamilton; Dipen Maru; Dejana Braithwaite; Scott Kopetz is a Medicine article available to read on EtoBox.
What is Epidemiology and Molecular-Pathologic Characteristics of CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer about?
## Background: Cpg island methylator phenotype (cimp) forms a distinct epigenetic phenotype in colorectal cancer (crc). though associated with distinct clinicopathologic characteristics, limited evidence exists of the association of cimp with patient's reported lifestyle factors and tumor molecular characteristics. we assessed the associations of these characteristics in a pooled analysis of crc patients. ## Patients and methods: We pooled data from 3 crc patient cohorts: assessment of targeted therapies against colorectal cancer (attacc), biomarker-based protocol (integromics), and the cancer genome atlas (tcga). cimp was measured using the classical 6-gene methylated-in-tumor (mint) marker panel (mint1, mint2, mint31, p14, p16, and mlh1) in attacc and genome-wide human methylation arrays in integromics and tcga, respectively. cimp-high (cimp-h) was defined as ≥ 3 of 6 methylated markers in attacc. in tcga and integromics, cimp-h group was defined on the basis of clusters of methylation profiles and high levels of methylation in tumor samples. baseline comparisons of characteristics across cimp groups (cimp-h vs. cimp-0) were performed by student t test or chi-square test for cont
Who reads Epidemiology and Molecular-Pathologic Characteristics of CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shailesh M. Advani; Michael D. Swartz; Jonathan Loree; Jennifer S. Davis; Amir Mehvarz Sarsashek; Michael Lam; Michael Sangmin Lee; Jan Bressler; David S. Lopez; Carrie R. Daniel; Van Morris; Imad Shureqi; Bryan Kee; Arvind Dasari; Eduardo Vilar; Michael Overman; Stanley Hamilton; Dipen Maru; Dejana Braithwaite; Scott Kopetz
- Publisher
- CIG Media Group, LP.; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 1533-0028)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)