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Ultrastructural localization of IGF-I in the rat kidney; an immunocytochemical study by G. L. Andersson; L. E. Ericson; E. Jennische is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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We have shown recently by light microscopy that insulin-like growth factor I (IGF-I) immunoreactivity is localized in cells in the collecting ducts and in the thin loop of Henle in the normal rat kidney. In the present study, we have investigated the ultrastructural localisation of IGF-I using preembedding immunocytochemistry. The light microscopical findings were confirmed at the electronmicroscopical level. In collecting ducts as well as in the thin limb of Henle's loop a focal expression of IGF-I immunoreactivity was evident, i.e. distinctly IGF-I positive cells were intermingled with cells lacking IGF-I immunoreactivity. IGF-I immunoreactivity was found to have a diffuse cytoplasmatic distribution in both cell types. No specific association to organelles was found.

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Author

G. L. Andersson; L. E. Ericson; E. Jennische

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 1432-119X)

Published

1990

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)