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Antibody–drug Conjugates and Bispecific Antibodies Targeting Cancers: Applications of Click Chemistry by Yeji Hong; Su-Min Nam; Aree Moon is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Antibody–drug Conjugates and Bispecific Antibodies Targeting Cancers: Applications of Click Chemistry about?

Engineering approaches using antibody drug conjugates (ADCs) and bispecific antibodies (bsAbs) are designed to overcome the limitations of conventional chemotherapies and therapeutic antibodies such as drug resistance and non-specific toxicity. Cancer immunotherapies have been shown to be clinically successful with checkpoint blockade and chimeric antigen receptor T cell therapy; however, overactive immune systems still represent a major problem. Given the complexity of a tumor environment, it would be advantageous to have a strategy targeting two or more molecules. We highlight the necessity and importance of a multi-target platform strategy against cancer. Approximately 400 ADCs and over 200 bsAbs are currently being clinically developed for several indications, with promising signs of therapeutic activity. ADCs include antibodies that recognize tumor antigens, linkers that stably connect drugs, and powerful cytotoxic drugs, also known as payloads. ADCs have direct therapeutic effects by targeting cancers with a strong payload. Another type of drug that uses antibodies are bsAbs, targeting two antigens by linking to antigen recognition sites or bridging cytotoxic immune cells to

Who reads Antibody–drug Conjugates and Bispecific Antibodies Targeting Cancers: Applications of Click Chemistry?

Author

Yeji Hong; Su-Min Nam; Aree Moon

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)