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Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait by Chul Hyoung Lyoo; Sargo Aalto; Juha O Rinne; Ki Ook Lee; Seung Hun Oh; Jin Woo Chang; Myung Sik Lee is a Medicine article available to read on EtoBox.
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## Abstract Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [^18^F]‐deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3% and the mFOG scores by 56.6%. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was
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- Author
- Chul Hyoung Lyoo; Sargo Aalto; Juha O Rinne; Ki Ook Lee; Seung Hun Oh; Jin Woo Chang; Myung Sik Lee
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)