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Biliary Diversion Increases Resting Energy Expenditure Leading to Decreased Blood Glucose Level in Mice with Type 2 Diabetes by Haixin Yin; Weijie Chen; Liangbo Dong; Shengnan Zhou; Fengying Gong; Xiaodong He is a Medicine article available to read on EtoBox.

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## Abstract ## Aims/Introduction Type 2 diabetes mellitus is a group of metabolism abnormalities in carbohydrates and energy. Our aim was to investigate resting energy expenditure (REE) and blood glucose changes after biliary diversion in mice with diabetes. ## Materials and Methods Male mice with diabetes were randomly divided into biliary diversion and sham groups. REE was detected by indirect calorimetry, the levels of fasting blood glucose, total bile acids and triiodothyronine were analyzed. After mice were killed, the weight amount of brown adipose tissue (BAT) and gastrocnemius was measured, and the expression level of G protein‐coupled bile acid receptor and type 2 iodothyronine deiodinase in BAT and gastrocnemius were examined. ## Results The two groups of mice were pair‐fed, the bodyweights (__P__ < 0.001) and the fasting blood glucose level (__P__ < 0.001) in the biliary diversion group significantly decreased 24 weeks after surgery. The intraperitoneal glucose tolerance test (__P__ = 0.035) and oral glucose tolerance test (__P__ = 0.027) showed improvement in glucose tolerance after surgery. The REE level significantly increased 24 weeks after surgery (__P__ = 0.005), t

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Author

Haixin Yin; Weijie Chen; Liangbo Dong; Shengnan Zhou; Fengying Gong; Xiaodong He

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)