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Structural analysis of the lipooligosaccharide from the commensal Haemophilussomnus strain 1P by Andrew D. Cox; Michael D. Howard; Thomas J. Inzana is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Structural analysis of the lipooligosaccharide from the commensal Haemophilussomnus strain 1P about?

The structure of the lipooligosaccharide (LOS) from the commensal Haemophilus somnus strain 1P was elucidated. The structure of the O-deacylated LOS was established by monosaccharide analysis, NMR spectroscopy and mass spectrometry. The following structure for the O-deacylated LOS was determined on the basis of the combined data from these experiments. [chemical structure: see text] In the structure Kdo is 3-deoxy-D-manno-octulosonic acid, Hep is L-glycero-D-manno-heptose and lipid A-OH refers to O-deacylated Lipid A. The elucidation of this structure has increased our understanding of the relationship between the variability in LOS structure and the pathogenic potential of this organism. Specifically, the inability of this commensal strain to sialylate its LOS suggests that LOS sialylation could be a crucial virulence factor for H. somnus.

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Author

Andrew D. Cox; Michael D. Howard; Thomas J. Inzana

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0008-6215)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)