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Expression of Stanniocalcin in Zona Glomerulosa and Medulla of Normal Human Adrenal Glands, and Some Adrenal Tumors and Cell Lines by Wakako Miura; Kazutoshi Mizunashi; Noriko Kimura; Yoshio Koide; Takao Noshiro; Yukio Miura; Yohtaro Furukawa; Hiroshi NagurA is a Medicine article available to read on EtoBox.
What is Expression of Stanniocalcin in Zona Glomerulosa and Medulla of Normal Human Adrenal Glands, and Some Adrenal Tumors and Cell Lines about?
Stanniocalcin (STC) is a calcium (Ca)‐regulating hormone that was originally discovered in the fish Stannius body, which is a unique endocrine organ. Hypercalcemia increases STC secretion, which inhibits Ca uptake by the gills and normalizes serum Ca level. In this study we investigated the STC expression in human normal and abnormal adrenal cells. Immunohistochemistry using monoclonal antibody against STC revealed specific staining in zona glomerulosa and medulla of normal human adrenal glands. STC was also detected in human adrenal tumors, such as pheochromocytoma, differentiated neuroblastoma, and aldosterone‐producing adenoma, and cultured adrenal tumor cells (rat pheochromocytoma PC‐12 cells and human neuroblastoma NB‐1 cells). However, undifferentiated human adrenal neuroblastoma was negative for STC staining. Reverse transcription polymerase chain reaction demonstrated STC mRNA expression in cultured PC‐12 cells and NB‐1 cells. Following several studies indicating that zona glomerulosa cells of adrenal glands express neuroendocrine properties, STC expression in normal and abnormal adrenal cells provides additional evidence to support the neuroendocrine differentiation of the
Who reads Expression of Stanniocalcin in Zona Glomerulosa and Medulla of Normal Human Adrenal Glands, and Some Adrenal Tumors and Cell Lines?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Wakako Miura; Kazutoshi Mizunashi; Noriko Kimura; Yoshio Koide; Takao Noshiro; Yukio Miura; Yohtaro Furukawa; Hiroshi NagurA
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0365-5555)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)