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Oral Probiotic Administration During Pregnancy Prevents Autism‐related Behaviors in Offspring Induced by Maternal Immune Activation via Anti‐inflammation in Mice by Xiao Wang; Junhua Yang; Hongyang Zhang; Jing Yu; Zhibin Yao is a Neuroscience article available to read on EtoBox.

What is Oral Probiotic Administration During Pregnancy Prevents Autism‐related Behaviors in Offspring Induced by Maternal Immune Activation via Anti‐inflammation in Mice about?

Maternal immune activation (MIA) is associated with an increased risk for autism spectrum disorders (ASD) in offspring. Animal experiments have found that interleukin 6 (IL‐6) and IL‐17a are key cytokines in the induction of ASD by MIA. Moreover, probiotics were verified to inhibit the production of proinflammatory cytokines. Therefore, we investigated whether the administration of oral probiotics during pregnancy might protect the offspring that have suffered MIA from developing ASD. Probiotics were orally administered to pregnant mice with/without the simultaneous administration of Poly(I:C). We found that oral probiotics prevented the ASD‐like behaviors induced by MIA in offspring. Furthermore, oral probiotics prevented the MIA‐induced increases in the IL‐6 and IL‐17a levels in both maternal serum and fetal brains, parvalbumin positive (PV^+^) neuron loss, and the decrease in the γ‐aminobutyric acid levels in the prefrontal cortex of adult offspring. This work suggests that administering oral probiotics during pregnancy may help decrease the risk of ASD following MIA during pregnancy. __Autism Res 2019, 12: 576–588__. © 2019 International Society for Autism Research, Wiley Perio

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Author

Xiao Wang; Junhua Yang; Hongyang Zhang; Jing Yu; Zhibin Yao

Publisher

Wiley

Published

2019

Language

EN

Field

Neuroscience (Life Sciences)