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Phytochemical analysis of medicinal plants of Nepal and their antibacterial and antibiofilm activities against uropathogenic Escherichia coli by Bhandari, Sudip (author);Khadayat, Karan (author);Poudel, Sami (author);Shrestha, Sunil (author);Shrestha, Raju (author);Devkota, Poonam (author);Khanal, Santosh (author);Marasini, Bishnu P. (author) is a Medicine article available to read on EtoBox.

What is Phytochemical analysis of medicinal plants of Nepal and their antibacterial and antibiofilm activities against uropathogenic Escherichia coli about?

## Background A biofilm is an extracellular polymeric substance (EPS) composed of polysaccharides, proteins, nucleic acids, and lipids that impede antibiotics and immune cells, thus providing a shielded environment for bacterial growth. Due to biofilm formation, some microbes can show up to 1000 fold increased resistance towards the antibiotics than the normal planktonic forms. The study was conducted to screen the crude extracts of medicinal plants used in Nepal for their in vitro antibiofilm activities. ## Methods Total phenolic and total flavonoid contents were determined by using a Folin-Ciocalteau reagent and aluminium trichloride method, respectively. Resazurin assay was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The initial antibiofilm activities and their inhibitory concentration (IC~50~) values were determined by the microtiter based modified crystal violet staining method. ## Results Out of 25 different plant extracts were used for the study, methanolic extracts of 20 plants showed a biofilm inhibition activity against five different strong biofilm producing __Escherichia coli__ strains. __Calotropis gigantea

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Author
Bhandari, Sudip (author);Khadayat, Karan (author);Poudel, Sami (author);Shrestha, Sunil (author);Shrestha, Raju (author);Devkota, Poonam (author);Khanal, Santosh (author);Marasini, Bishnu P. (author)
Publisher
Springer Science and Business Media LLC
Published
2021
Language
EN
Field
Medicine (Health Sciences)

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