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Can I read Synthesis and in Vitro Antimalarial Activity of Sulfone Endoperoxides on EtoBox?
Synthesis and in Vitro Antimalarial Activity of Sulfone Endoperoxides by Mario D. Bachi; Edward E. Korshin; Poonsakdi Ploypradith; Jared N. Cumming; Suji Xie; Theresa A. Shapiro; Gary H. Posner is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and in Vitro Antimalarial Activity of Sulfone Endoperoxides about?
A series of 4,8-dimethyl-4-phenylsulfonylmethyl-2,3-dioxabicyclo[3.3.1]nonanes, carrying a variety of substituents at position-8 (4) were prepared by a short and efficient method from R-(+)-limonene. Key reactions include thiol oxygen cooxidation, and alkylation and acylation of a sterically hindered tertiary alcohol compatible with the endoperoxy functionality. Some of compounds 4, which are structurally related to yingzhaosu A (2), were found to exhibit in vitro antimalarial activity comparable to that of artemisinin (1) and superior to that of arteflene (3).
Who reads Synthesis and in Vitro Antimalarial Activity of Sulfone Endoperoxides?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Mario D. Bachi; Edward E. Korshin; Poonsakdi Ploypradith; Jared N. Cumming; Suji Xie; Theresa A. Shapiro; Gary H. Posner
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 1998
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)