Can I read Molecularly imprinted polymers for corticosteroids: Analysis of binding selectivity on EtoBox?

Molecularly imprinted polymers for corticosteroids: Analysis of binding selectivity by Claudio Baggiani; Patrizia Baravalle; Cristina Giovannoli; Laura Anfossi; Gianfranco Giraudi is a Engineering article available to read on EtoBox.

What is Molecularly imprinted polymers for corticosteroids: Analysis of binding selectivity about?

In this work we prepared a library of cortisol-imprinted polymers via a sequential approach by combining 10 different functional monomers, 7 cross-linkers and 5 porogen solvents. The best combinations of functional monomers, cross-linkers and porogen solvents in terms of cortisol binding were used to prepare three imprinted polymers -polyacrylamide-co-ethylene dimethacrylate (porogen: chloroform), poly-4-vinylpyridine-co-ethylene dimethacrylate (porogen: chloroform) and polyacrylamide-co-ethylene dimethacrylate (porogen: acetonitrile) -whose selectivity towards 10 synthetic corticosteroids and 4 natural steroidal hormones was tested. The experimental results obtained show how different combinations of functional monomers, cross-linkers and porogen solvents produce cortisol-imprinted polymers with very different selectivity patterns, and that a careful optimization of the pre-polymerization mixtures makes it possible to increase the number of target steroids recognized by the resulting imprinted polymer. Moreover, through the use of a Free-Wilson analysis of the binding selectivity, it has been possible to obtain insights on the steroidal structural motifs able to increase or decrea

Who reads Molecularly imprinted polymers for corticosteroids: Analysis of binding selectivity?

Author

Claudio Baggiani; Patrizia Baravalle; Cristina Giovannoli; Laura Anfossi; Gianfranco Giraudi

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0956-5663)

Published

2010

Language

EN

Field

Engineering (Physical Sciences)