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Theory of Antimicrobial Combinations: Biocide Mixtures - Synergy or Addition? by R.J.W. Lambert; M.D. Johnston; G.W. Hanlon; S.P. Denyer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Theory of Antimicrobial Combinations: Biocide Mixtures - Synergy or Addition? about?

## Aims: To demonstrate the effect that non-linear dose responses have on the appearance of synergy in mixtures of antimicrobials. ## Methods and results: A mathematical model, which allows the prediction of the efficacy of mixtures of antimicrobials with non-linear dose responses, was produced. the efficacy of antimicrobial mixtures that would be classified as synergistic by time-kill methodology was shown to be a natural consequence of combining antimicrobials with non-linear dose responses. ## Conclusions: The effectiveness of admixtures of biocides and other antimicrobials with non-linear dose responses can be predicted. if the dose response (or dilution coefficient) of any biocidal component, in a mixture, is other than one, then the time-kill methodology used to ascertain the existence of synergy in antimicrobial combinations is flawed. ## Significance and impact of the study: The kinetic model developed allows the prediction of the efficacy of antimicrobial combinations. combinations of known antimicrobials, which reduce the time taken to achieve a specified level of microbial inactivation, can be easily assessed once the kinetic profile of each component has been obtained.

Who reads Theory of Antimicrobial Combinations: Biocide Mixtures - Synergy or Addition??

Author

R.J.W. Lambert; M.D. Johnston; G.W. Hanlon; S.P. Denyer

Publisher

Oxford University Press (OUP)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)