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Utilization and Efficacy of Palliative Chemotherapy for Locally Advanced or Metastatic Gastroesophageal Carcinoma by RUTH BAUMGARTNER; HOSSEIN TAGHIZADEH; GERD JOMRICH; SEBASTIAN FRIEDRICH SCHOPPMANN; MATTHIAS PREUSSER; AYSEGUL ILHAN-MUTLU is a Medicine article available to read on EtoBox.
What is Utilization and Efficacy of Palliative Chemotherapy for Locally Advanced or Metastatic Gastroesophageal Carcinoma about?
## Background/aim: A standard treatment recommendation for advanced stage gastroesophageal cancer is still missing. ## Patients and methods: We retrospectively analyzed clinical data of patients with inoperable locally advanced or metastatic gastroesophageal cancer treated between 2001 and 2017 at the vienna general hospital, austria. ## Results: Administration of systemic therapy was positively associated with overall survival (os) (469 days vs. 185 days; p<0.001), while palliative gastrectomy or radiotherapy showed no correlation. os was significantly longer in patients receiving capecitabine/oxaliplatin (xelox) vs. leucovorin/5-fu/oxaliplatin (folfox) (600 days vs. 327 days, p<0.05). comparison of doublet vs. triplet chemotherapies showed no difference in os, but triplet chemotherapy resulted in more adverse events. the anti-her2-antibody trastuzumab doubled os (836 days vs. 399 days, p=0.053). ## Conclusion: Capecitabine may be preferably used over infused 5-fu and doublet chemotherapy over triplet chemotherapy in the first-line palliative setting of advanced gastroesophageal cancer.
Who reads Utilization and Efficacy of Palliative Chemotherapy for Locally Advanced or Metastatic Gastroesophageal Carcinoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- RUTH BAUMGARTNER; HOSSEIN TAGHIZADEH; GERD JOMRICH; SEBASTIAN FRIEDRICH SCHOPPMANN; MATTHIAS PREUSSER; AYSEGUL ILHAN-MUTLU
- Publisher
- International Institute of Anticancer Research; Anticancer Research USA Inc. (ISSN 0250-7005)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)