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Can I read Excretion of 3-Hydroxy-benzo(a)pyrene and Mutagenicity in Rat Urine After Exposure to Benzo(a)pyrene on EtoBox?
Excretion of 3-Hydroxy-benzo(a)pyrene and Mutagenicity in Rat Urine After Exposure to Benzo(a)pyrene by F. J. Jongeneelen; Ch. M. Leijdekkers; R. P. Bos; J. L. G. Theuws; P. Th. Henderson is a Environmental Science article available to read on EtoBox.
What is Excretion of 3-Hydroxy-benzo(a)pyrene and Mutagenicity in Rat Urine After Exposure to Benzo(a)pyrene about?
3-hydroxy-benzo(a)pyrene (3-OH-B(a)P) and mutagenic activity in rat urine were determined after the oral administration of benzo(a)pyrene given in three repeated doses of 10, 20 and 50 pmol kg-'. The procedure for the determination of 3-OH-B(a)P consisted of enzymic hydrolysis, separation and HPLC-analysis. The mutagenic activity of concentrated urine samples was assayed with the Salmonella typhimurium strain TA98 in the presence of S9 mix and 0-glucuronidase. The urinary excretion of 3-OH-B(a)P and mutagens showed a correlation and both increased dose-dependently during the sampling period of 6 days. Data indicated that 3-OH-B(a)P can be regarded as a reliable representative of all urinary (pre)-mutagens derived from benzo(a)pyrene and exposure of rats to benzo(a)pyrene could be detected with greater sensitivity by the HPLC assay of 3-OH-B(a)P than with the non-specific mutagenicity assay.
Who reads Excretion of 3-Hydroxy-benzo(a)pyrene and Mutagenicity in Rat Urine After Exposure to Benzo(a)pyrene?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- F. J. Jongeneelen; Ch. M. Leijdekkers; R. P. Bos; J. L. G. Theuws; P. Th. Henderson
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0260-437X)
- Published
- 1985
- Language
- EN
- Field
- Environmental Science (Physical Sciences)