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Integrative analysis of AR‐mediated transcriptional regulatory network reveals IRF1 as an inhibitor of prostate cancer progression by Cheng, Yihang; Wang, Dan; Jiang, Jun; Huang, Wenhua; Li, Dujian; Luo, Jun; Gu, Wei; Mo, Wenjuan; Wang, Chenji; Li, Yao; Gu, Shaohua; Xu, Yaoting is a Medicine article available to read on EtoBox.
What is Integrative analysis of AR‐mediated transcriptional regulatory network reveals IRF1 as an inhibitor of prostate cancer progression about?
## Background: Androgen receptor (ar) is crucial for prostate cancer (pca) initiation and malignant progression. only half of androgen-responsive genes have been identified as having androgen-responsive elements, suggesting that ar regulates downstream genes through other transcriptional factors. however, whether and how ar regulates the progression via regulating these androgen-responsive genes remains unclear. ## Methods: Androgen-responsive and activity-changed (ac) transcriptional factors (tfs) were identified based on the time-course gene-expression array and gene promoter regions analysis. the intersection of androgen-responsive and ac tfs was selected the core tfs, which were used to construct the core transcriptional regulatory network. go enrichment analysis, cell proliferation assays, glycolysis experiments, and reverse transcription polymerase chain reaction analysis were used to analyze and validate the functions of the network. as one of the core tfs, the function and mechanism of irf1 have been further explored. ## Results: We devised a new integrated approach to select core tfs and construct core transcriptional regulatory network in pca. the 24 core tfs and core tra
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- Author
- Cheng, Yihang; Wang, Dan; Jiang, Jun; Huang, Wenhua; Li, Dujian; Luo, Jun; Gu, Wei; Mo, Wenjuan; Wang, Chenji; Li, Yao; Gu, Shaohua; Xu, Yaoting
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)